1
Ptide absorbed to CAP was consistent with an -helix, whereas when bound to HA the structure corresponded more to a random coil [107]. We studied DPP peptides by FTIR spectroscopy and found the phosphorylated peptides in solution in the presence of HA formed -helical structures and lost their random coil characteristics [108]. Perhaps, through evolution, the most efficient strategy found by nature
1
Hinge region of type VII collagen, associated with dystrophic epidermolysis bullosa, is also intrinsically disordered [67]. Additionally, the SIBLING proteins, all IDPs, are also associated with vascular [68,69] and other soft tissue calcifications [70]. Since their genes are expressed in cells associated with these deposits they cannot have accumulated simply due to their affinities for HA or col