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The antibodies are involved in release of complement and anaphylatoxins which can cause or exacerbate DHF/DSS. These systems are inextricable and strongly associated with dengue pathogenesis.Dengue Background and SignificanceThe Dengue Virus is a member of the family Flaviviridae along with other noted viruses Yellow Fever, West Nile, and Japanese Encephalitis. Dengue is a positive stranded RNA ar
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The antibodies are involved in release of complement and anaphylatoxins which can cause or exacerbate DHF/DSS. These systems are inextricable and strongly associated with dengue pathogenesis.Dengue Background and SignificanceThe Dengue Virus is a member of the family Flaviviridae along with other noted viruses Yellow Fever, West Nile, and Japanese Encephalitis. Dengue is a positive stranded RNA ar
1
Egins with dengue infection of dendritic cells that, in turn, promiscuously activates T cells. T cells during a dengue infection have prolific and cross reactive effector functions in addition to producing copious amounts of cytokines that feature prominently in cases of DHF/DSS. A second component in immune enhancement is Antibody Dependant Enhancement (ADE). Heterologus non-neutralizing antibodi
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Rough a time consuming and multiphase process that lasts anywhere from 6-24 hours. Adhesion molecules such as ICAM1 and ICAM3 are critical molecules generated by the T-cell during either phase and can bind to the adhesion molecules of DCs particularly DC-SIGN which is a known target of dengue. These molecules are necessary to form a stable synapse between the DC and T-cell[23]. T-cells, in turn, p
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En present with fever, rash, headache, and myalgia but can also develop into much more serious cases of Dengue Hemorrhagic Fever and Dengue Shock Syndrome (DHF/DSS). Cases of DHF/DSS are increasing rapidly as the virus increases in geographic range, with approximately 25-37 of symptomatic cases of denguePage 1 of(page number not for citation purposes)Virology Journal 2009, 6:http://www.virologyj.
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Egins with dengue infection of dendritic cells that, in turn, promiscuously activates T cells. T cells during a dengue infection have prolific and cross reactive effector functions in addition to producing copious amounts of cytokines that feature prominently in cases of DHF/DSS. A second component in immune enhancement is Antibody Dependant Enhancement (ADE). Heterologus non-neutralizing antibodi
1
Ntegrin) (CD209) on dendritic cells [17-19]. Dendritic cells are considered crucial to fighting viral infections because of their ability to acquire and display viral antigens that would otherwisePage 2 of(page number not for citation purposes)Virology Journal 2009, 6:http://www.virologyj.com/content/6/1/evade the immune system. Dendritic cells affect the dengue virus in two ways. Immature dendrit
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Risk. Mild dengue fever presents with headache, fever, rash, myalgia, osteogenic pain, and lethargy. Severe disease can manifest as dengue shock syndrome (DSS) or dengue hemorrhagic fever (DHF). Symptoms of DSS/DHF are leukopenia, low blood volume and pressure encephalitis, cold and sweaty skin, gastrointestinal bleeding, and spontaneous bleeding from gums and nose. Currently, there are no therape

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