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That provides selection and propagation in host bacteria. Although the exactThat provides selection and propagation in host bacteria. Although the exact mechanism by which DNA vaccines work still remains unclear recent advances have provided a deeper , understanding of the molecular and immunological [12-14] mechanisms of action of these vectors . Generally, once the DNA plasmid is administe
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To protein Variable degree of carrier immunogenicity; need adjuvants (and oftenTo protein Variable degree of carrier immunogenicity; need adjuvants (and often multiple doses); frequent local reactions at the injection siteHumoral immunityDiphtheria; tetanus; pertussis; haemophilus influenzae type b; poliomyelitis; rabies; meningitidis; Japanese encephalitis; cholera; hepatitis A; hepatitis B
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Luble/secreted plasmid product may simultaneously gain access to the majorLuble/secreted plasmid product may simultaneously gain access to the major histocompatibility complex (MHC) class II exogenous pathway in phagocytic cells, for the [15] activation of B cells, CD4+ and CD8+ T lymphocytes . Many reports emphasized on the ability of DNA vaccines to induce immune responses against a variet